Category: cDNA

Loss of Olfactory Function-Early Indicator for Covid-19, Other Viral Infections and Neurodegenerative Disorders
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Loss of Olfactory Function-Early Indicator for Covid-19, Other Viral Infections and Neurodegenerative Disorders

The lack of the senses of odor (anosmia) and style (ageusia) are fairly frequent problems, affecting as much as 20%…

Therapeutic Role of Inflammasome Inhibitors in Neurodegenerative Disorders
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Therapeutic Role of Inflammasome Inhibitors in Neurodegenerative Disorders

Neuroinflammation, characterised by the activation of glial cells, is a trademark in a number of neurological and neurodegenerative issues. Insufficient…

Flavonoids targeting NRF2 in neurodegenerative disorders
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Flavonoids targeting NRF2 in neurodegenerative disorders

Neurodegenerative issues are characterised by progressive lack of neurons. So far, no efficacious therapies exist for these issues, and present…

PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders
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PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders

Neurodegenerative ailments characterize a number of the most devastating neurological problems, characterised by progressive lack of the construction and performance…

Dysfunctional glia: contributors to neurodegenerative disorders
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Dysfunctional glia: contributors to neurodegenerative disorders

Astrocytes are integral elements of the central nervous system, the place they're concerned in quite a few features crucial for…

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy.
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Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy.

Aging-related failure of homeostatic mechanisms contribute to articular cartilage degeneration and osteoarthritis (OA), which are disease-modifying treatments are not available.…

The first wide-scale drug repurposing screen using the Prestwick Chemical Library (1200 bioactive molecules) against Neisseria gonorrhoeae identifies high in vitro activity of auranofin and many additional drugs.
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The first wide-scale drug repurposing screen using the Prestwick Chemical Library (1200 bioactive molecules) against Neisseria gonorrhoeae identifies high in vitro activity of auranofin and many additional drugs.

Treatment options for gonorrhea are rare. repurposing bioactive molecule drugs approved for other conditions as it may be of value.…

HIV Drugs Inhibit Transfer of Plasmids Carrying Extended-Spectrum β-Lactamase and Carbapenemase Genes.
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HIV Drugs Inhibit Transfer of Plasmids Carrying Extended-Spectrum β-Lactamase and Carbapenemase Genes.

Antimicrobial resistant (AMR) infections pose a serious risk to human and animal health. The main factors that contribute to this…

High Content Screening Using New U2OS Reporter Cell Models Identifies Harmol Hydrochloride as a Selective and Competitive Antagonist of the Androgen Receptor
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High Content Screening Using New U2OS Reporter Cell Models Identifies Harmol Hydrochloride as a Selective and Competitive Antagonist of the Androgen Receptor

Prostate cancer is the most frequently diagnosed malignancy in men. growth is primarily dependent on the activity of the androgen…